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Sleep and Aging

The Impact of PAP Therapy on Cardiovascular Risk and Mortality

By Heart Health, Selected Articles, Sleep and Aging, Sleep Apnea, Treatment No Comments

Positive airway pressure (PAP) use is associated with lower all-cause mortality and lower incidence of major adverse cardiovascular events (MACE) among older adult patients with sleep apnea, according to recent findings published in JAMA Network Open.

This large retrospective cohort study evaluated mortality and health outcomes among 888,835 Medicare beneficiaries with obstructive sleep apnea over a median follow-up period of 3.1 years. The researchers found that initiating PAP therapy was associated with a significant reduction in the risk of both all-cause mortality and MACE, including heart attack, stroke, and heart failure.

These findings underscore the critical importance of early diagnosis and treatment of sleep apnea to improve long-term health outcomes.

Identifying Sleep Apnea

Sleep apnea often goes undiagnosed. Common symptoms include snoring, gasping or choking during sleep, morning headaches, and daytime sleepiness.

Risk factors for sleep apnea include high body mass index (BMI), obesity, older age, and certain anatomical features (e.g., enlarged tonsils, upper airway abnormalities). Use of tobacco, alcohol, and certain sedative and pain medications can worsen apnea severity.

Sleep apnea frequently co-occurs with other health conditions, including heart disease, stroke, hypertension, gastroesophageal reflux disease (GERD), hyperlipidemia, and type 2 diabetes.

Undiagnosed Sleep Apnea Linked to Accelerated Aging, New Study Finds – Everyday Health

By Sleep and Aging, Sleep Apnea, Women's Health No Comments

Untreated obstructive sleep apnea and other sleep-disordered breathing problems may accelerate aging, according to a study abstract published in the journal Sleep.

Researchers at Harvard Medical School examined blood samples from 622 participants with untreated sleep disordered breathing to look for epigenetic changes in their DNA. Epigenetics refers to changes in the DNA that result from lifestyle and environmental factors. Such changes can affect how genes behave, as well as biological aging.

The researchers found that sleep-disordered breathing is linked to accelerated epigenetic aging, or early aging of the DNA within cells, and that this association increases with the severity of sleep breathing problems. 

The data also showed that sleep disordered breathing leads to more significant epigenetic changes and accelerated aging in women than in men.

Fortunately, epigenetic changes are reversible, and sleep apnea is treatable. Understanding the effect of sleep apnea on aging would have significant implications for better health and longevity.